The second part of the experiment was recrystallization. Perhaps, the sample was not weighed properly or it was weighed when still wet. In the following experiment, Aspirin was synthesized and analyzed in a laboratory setting in order to recognize the chemical process behind a common drug like aspirin and to relate it to the conceptual study of organic chemistry.
Salicylic acid was a white, chalky powder; acetic anhydride a clear, colorless liquid; and phosphoric acid a clear, yellow-tinted liquid. Acetylsalicylic acid, also known as aspirin, is one of the most widely used medications to reduce fever and is also used as a pain killer.
Acetic anhydride gave a positive result to water solubility test to form acetic acid. The recrystallized product was differentiated from commercial aspirin through iodine test and it showed that the commercial aspirin contains starch. Phosphoric acid was used as a catalyst. Since aspirin has a hydrophobic aromatic ring, it did not dissolve in water.
As shown in the above reaction, phosphoric acid, H3PO4 acts as a catalyst in the initial mixture of the reactants in order to speed up the reaction. After dissolving synthesized aspirin in 2mL water and 1mL iodine solution, a mixture of red-orange liquid and white precipitates was obtained while when commercially available aspirin was dissolved in 2mL water and 1mL iodine solution, a black precipitate in a dark brown to black solution was formed.
The starting reading of NaOH was recorded.
This is quite far from the theoretical yield because it still contains impurities. Aspirin, acetylsalicylic acid, is a familiar drug, used for relieving cold and flu symptoms, fevers, and general aches and pains in the body, and, as made clear by its chemical formula, contains salicin — a chemical found in willow bark.
A white, milky mixture was obtained when salicylic acid, acetic anhydride and phosphoric acid a catalyst were mixed. The weight of the recovered sample was 2. In this part, purification is not yet complete it was continued on the recrystallization part.
The mechanism of the reaction is: The calculations for percent yield was shown in Table 6. The crystals were then washed three times with the vacuum using 5 mL amounts of DI water.
In this manner, acetic anhydride was decomposed after the formation of aspirin.The Synthesis of Organic Aspirin ABSTRACT: Title Page Introduction Synthesis of a Cobalt Complex Percent Halide Analysis of Cobalt Complex Preparation and Standardization of a M Hydrochloric Acid solution Percent Ammonia Analysis of Cobalt Complex Preparation and Standardization of a M Sodium.
Preparation, Purification and Analysis of Aspirin (acetylsalicylic acid) Synthesis: We will prepare aspirin by reacting salicylic acid 1 with an excess of acetic anhydride 2 to produce aspirin. Aspirin Synthesis Experiment 5. 2 The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form of salicylic acid (salicylate ion) to give a purple solution.
Only the salicylate ion complexes to iron(III). Your.
May 23, · Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials.
The objective of organic synthesis is to design the simplest synthetic routes to a molecule. After aspirin synthesis was complete, the aspirin was analyzed using both IR and NMR spectrometers in order to determine the hydrogen atoms and organic functional groups present in the synthesized aspirin and to verify the overall identity of the aspirin.
ingredient of Aspirin) is an acetyl derivative of salicylic acid and the prodrug of the active metabolite, salicylic acid.2 Aspirin is a salicylate drug because it is an ester of salicylic acid. It is commonly known for its pain relieving properties.Download